Pesticide labels accompanied by colored and pictorial messages play a crucial role in communicating information regarding toxicity and safety precautions towards safe agriculture. This study evaluated the effectiveness of label information including pictograms, and color codes among farming communities of high-, middle-, and low-income countries. In ten out of fourteen studies, more than 50% of farmers recorded low readability and comprehensibility of label information. Similarly, color codes and pictograms were poorly interpreted where countries with economic classifications showed no considerable difference. Interestingly, only younger, well-educated, trained, and experienced farmers displayed a positive attitude toward safe use, and comprehension of pictograms.